glutathione sepharose regeneration Schematic diagram showing the conversion of (GSH) from the linked agarose In-house preparation of hydrogels for – well spin plate formats for processing up to 96 samples Schematic representation of the structure

These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19

Moreover, prospective studies have reported increased cases of autoimmune diseases in families of children with ASD, especially in mothers (Ashwood and Van De Water, 2004)

doi: 10.1016/j.bcp.2017.02.009 40 ChalmersJDBurgelP-RDaleyCLDe SoyzaAHaworthCSMaugerDet al

2019 Apr 1;85:44-52

The nonenzymatic functions of GSTs involve their interactions with cellular proteins, such as, Jun N-terminal kinase,(JNK), tumor necrosis factor receptor-associated factor-2 (TRAF2), apoptosis-signal-regulating kinase 1 (ASK), serine/threonine kinases (PKA, PKC), and tissue transglutaminase 2 (TGM2), during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered [53], [74]