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High overexpression of SLC7A11 promotes primary tumor growth but suppresses tumor metastasis The oxidizing environment in the blood contributes to the highly inefficient nature of metastasis

Liao F, Yao C, Wu T, Chen S, Yeh L, Lin S, Lin W

It signals via a completely different biochemical pathway than GHRH

While macrophage-specific knockout of ATP citrate lyase stabilized murine plaques and showed dysregulated cholesterol and fatty acid metabolism, main effects seemed to be exerted via changes in apoptosis ( Fumarate accumulation in -glucan trained monocytes increases histone methylation associated with an increased pro-inflammatory gene transcription of TNF and IL-6 (Liu et al., 2017)

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