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Renal scarring is the most significant predictor of breakthrough febrile urinary tract infection in patients with simplex and duplex primary vesico-ureteral reflux

Preclinical studies confirmed that it stimulates lipolysis by upregulating beta-3 adrenergic receptor (beta-3 AR) expression in adipose tissue, restoring the lipolytic responsiveness that is suppressed in obese animals

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The proposed methodology modifies the assignment of those achievement points such that MIPS eligible clinicians performing near the median for a cost measure would be more likely to receive a neutral score consistent with the performance threshold than a negative score, which they would be more likely to receive under the current scoring methodology