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While their clinical use is supported by an expanding body of research in functional and regenerative medicine, they are not FDA-approved for all indications

Leber's hereditary optic neuropathy: This injection should be avoided in patients with this genetic eye disorder as it may worsen their condition

"Pharmacist Rounds: Surgical Irrigation Fluids--To Warm or Not-Although the jury is still out, the majority of published reports support the use of warm irrigation fluids to minimize the risk of hypothermia in surgical procedures." Pharmacy Times 75.8 (2009): 56

doi: 10.1097/GOX.0000000000002160

Clinical characteristics of patients in the study Figure 2 Discussion This is the first study examining the long-term treatment response of neuropathic pain with BoNT