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In this review, we discuss how PTMs of RBPs influence the formation of cytoplasmic protein aggregates by phase separation in the pathogenesis of ALS and summarize recent studies describing the effects of PTMs in RBPs during the pathological phase transition of ALS

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Despite these challenges, by providing information about underlying pathological processes, imaging and fluid biomarkers bring important opportunities to enhance diagnostic frameworks, enable early diagnosis, capture underlying causes of heterogeneity of PD, and quantitatively track disease progression

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-Glutamyl-dipeptides: Easy Tools to Rapidly Probe the Stereoelectronic Properties of the Ionotropic Glutamate Receptor Binding Pocket