interaction of chloroacetamide electrophiles with cellular glutathion Targeting a Therapy-Resistant Cancer Cell State Using Masked as GPX4 Inhibitors Identification, optimization, and structural elucidation
Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C terminal Hydrolase L3 bioRxiv Glutathione Dynamics in Subcellular Compartments and Implications for Drug Development PMC Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis Chevallier 2020 Biotechnology and Bioengineering Wiley Online Library Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2 Ethynylthiazole 4 carboxamide as Electrophilic Warhead Journal of Medicinal Chemistry
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