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In a mouse chronic exposure model, pyocyanin polarizes an initially Th1 immune response towards the IL-4 and IL-13-dominated Th2 response, activating the IL-4/IL-13 receptor-STAT6-SPDEF signaling pathway (186, 195)

For optimal absorption, adults take 2 capsules daily on an empty stomach or in between meals with water

It is unknown whether our patients were taking supplements specifically to manage ME/CFS symptoms and whether they initiated use on their own or on the advice of a clinician

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