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10.1016/j.toxicon.2018.05.022 11 CrijnsA

The proteomic analysis of U87 cells treated with hBN showed modulation of protein markers associated with M2 polarization of microglia cells to promote anti-inflammatory and tissue repair functions whereas, the apoptosis and Ki67 analysis showed anti-glioma effects [86]

As a key enzyme in the tricarboxylic acid cycle, MDH2 play a non-metabolic role in ccRCC progression by reducing FSP1 protein levels and increasing the ccRCCs sensitivity to ferroptosis (148)