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The first breakpoint occurs at the downregulated isocitrate dehydrogenase (IDH) 1, which converts isocitrate into -ketoglutarate (-KG) in M2, resulting in citrate accumulation, facilitating the biosynthesis of fatty acids and prostaglandins in M1 macrophages [12]

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Data portal for the library of integrated network-based cellular signatures (LINCS) program: Integrated access to diverse large-scale cellular perturbation response data