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Nature 571 (7764), 183192 (2019)

This 5:1:1:1 ratio is not arbitrary

2.4 Gene Expression Modulation: Genomic studies (e.g., Pickart et al., 2012) reveal GHK-Cu resets over 4,000 genes to a youthful state, upregulating repair genes and downregulating inflammatory ones, a unique epigenetic effect