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Cyanocobalamin produces trace amounts of free cyanide during metabolism, and while this is clinically insignificant in people with normal kidney function, impaired renal clearance could theoretically allow accumulation

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"Cold, harsh temperatures and reduction in humidity due to central heating can contribute to drying them out, confirms Dr Kluk

Treatment with tiagabine, a GABA reuptake inhibitor, showed prolongation of lifespan in Rett mice (69)

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders