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In the process of immunotherapy, cytokines directly stimulate immune effector cells in tumor sites, enhance cytotoxicity, and enable immune cells to communicate in a short distance (104)

the liposomes may also comprise cholesterol or other sterols such as plant sterols where the weight ratio of the phospholipid to sterol is between about 5:1 and 20:1, and more preferably about 10:1

Both complete loss-of-function and reduced function variants may result in a reduction of treatment efficacy, with atypical metabolite formation (e.g., switching from coumarin 7-hydroxylation to 3-hydroxylation) (Hadidi et al., 1997

To this end, we first investigated whether NHR-49 activity could recover upon refeeding

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