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PARP-1 (poly-ADP-ribose polymerase 1) is a DNA repair enzyme that consumes NAD + to synthesize poly-ADP-ribose chains at damage sites

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Although nerve conduction studies or somatosensory evoked potentials can identify abnormalities when the spinal MRI appears normal, their clinical utility in elderly patients is limited, and prompt empirical treatment with vitamin B12 is generally preferable to invasive diagnostic testing

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