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Success requires physician supervision, objective body composition monitoring (not just scale weight), and integration with proper nutrition and exercise foundations for optimal metabolic outcomes

The effects go beyond physical changes - men often experience mood swings, irritability, depression, anxiety, and lose their drive [1]

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It is important to note that the glucose-raising effect of glucagon receptor activation is largely counterbalanced by the GLP-1 and GIP components

Some of these dogs also showed clinical signs suggestive of enteropathy, such as diarrhea and a failure to gain weight