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Elevated markers of the integrated stress response and unfolded protein response have been identified in postmortem samples from patients with nongenetic ALS [224, 232]

Radiation can inhibit the expression of SLC7A11, which affects cystine uptake and leads to GSH depletion ( 3.3 The role of the p53 protein in the regulation of ferroptosis due to radiotherapy p53 plays a critical role in regulating the ferroptosis pathway

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