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In animal models of HD, atrophic astrocytes in striatum retract their leaflets from cortico-striatal synapses, which are known to be affected in the early HD

A single-cell atlas of entorhinal cortex from individuals with Alzheimers disease reveals cell-type-specific gene expression regulation

For instance, addition of amine containing constituents on the cells surface through lysinylation of teichoic acids and/or lipids, as well as deacetylation of peptidoglycan, may provide a nucleophile reactivity barrier that prevents 4-HNE entry into the bacterial cell

A possible infectious cause was first proposed as an explanation for this intriguing observation, but recent data have strengthened the genetic-immunologic theory (170, 174, 175)

6 Characterization of Lysine 48 mutants of GPX4 in silico