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This important preclinical study showed that ketamine and other NMDAR antagonists produce fast-acting antidepressant-like effects in mouse models that depend on the rapid synthesis of BDNF via a mechanism that includes the deactivation of eEF2 kinase

Patients were divided into 3 groups according to the duration of the disease, 22 patients in the 1 group with a duration of 13 years, 22 patients in the 2group with a duration of 35 years, and 22 patients in the 3group with a duration of 57 years

doi: 10.1016/j.autneu.2013.12.003 126 CarlsonABKrausGP

10.1186/s13023-014-0141-5 151 SumnerA

Allergic reactions to GHK-Cu are extremely rarely documented in the literature, with individuals who have a known copper intolerance or Wilson's disease being an exception