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Mild symptoms can include: Pale skin Feeling irritable Loss of appetite Diarrhea or constipation Feeling short of breath when exercising Swollen and red tongue or bleeding gums Feeling tired or lightheaded with light exertion If your vitamin B12 stays low for a longer period of time, your nerves may experience some damage, which can cause other, more serious symptoms such as: Confusion Hallucinations Trouble concentration Having trouble balancing Numbness and tingling in your hands and feet Recommended Daily Intake of Vitamin B12 For most adults, health professionals recommend taking 2.4 mcg of B12 daily

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Finally, a key regulatory factor in the Warburg effect lies in the combined capacity of the malate-aspartate shuttle (MAS) and the glycerol-3-phosphate shuttle (G3PS)