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1 Introduction Epilepsy is one of the most common chronic and heterogeneous neurological disorders, affecting more than 60 million individuals worldwide (Mosh et al., 2015)

In this review we discuss how HAART is known to influence mtDNA integrity, alter mitochondrial morphology and function, induce oxidative stress, inflammation, and cell senescence, and how it is directly connected to aging symptoms and co-morbidities

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In summary, advancing the field of human neuroprotection demands a multidimensional recalibration, spanning conceptual clarity, more representative preclinical models, validated biomarkers, and refined clinical endpoints