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Usually, conventional selenium dietary supplements exhibit a low degree of absorption and enhanced toxicity [58]

Many metabolites, particularly those involved in the metabolism of iron, lipids, amino acids and lactate, regulate the complicated ferroptotic response by directly or indirectly regulating iron accumulation or lipid peroxidation in cancer cells

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Table 9 Vitamin B6 is dependent upon FAD for its activation to pyridoxine 5 phosphate (PLP) and adequate levels of activated vitamin B6 are required for both serotonin synthesis by l-tryptophan hydrolase and metabolism of serotonins precursor substrate l-tryptophan in the first part of the kynurenic pathway