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It participates in the regulation of fatty acid metabolism, bile acid synthesis and energy metabolism, helps maintain the balance of fat and sugar, and thus has a preventive and therapeutic effect on metabolic diseases such as metabolic syndrome and diabetes

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Its various mechanisms, including its antioxidant effects, the stimulation of pheomelanin synthesis instead of eumelanin, and interference with intracellular trafficking of melanogenic enzymes, contribute to its antimelanogenic properties.3 Hence, through the histopathological examination of melanocyte activity, location of melanin pigment deposition, and response after therapy, we can determine the effects of glutathione on skin color.6,9 However, Arjinpathana and Asawanonda1 reported many contradictory results regarding the efficacy and safety of glutathione as a skin-lightening agent

22 Conditions such as aging, hypertension, ischemic heart disease, diabetes, and chronic lung disease are associated with decreased baseline GSH levels, while smoking, obesity, alcoholism, renal failure, cancers, and other chronic diseases are linked to disruptions in GSH homeostasis, impairing glutathione functionality

doi:10.1016/j.brainres.2010.11.078