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Duro JC, Porta M, et al

Food and Drug Administration (FDA) (2022)

Initial catabolism of MeGx occurs via the glyoxalase pathway 12,13 , which consists of glyoxalase I (Glo1, enzyme commission number 4.4.1.5, lactoylglutathione lyase) and glyoxalase II (Glo2, enzyme commission number 3.1.2.6, hydroxyacylglutathione hydrolase), which in red blood cells (RBCs) have a maximum flux capacity ~100 times that of glycolysis 14,15