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While SASP activation supports tumor suppression and tissue repair processes, it simultaneously promotes chronic inflammatory states and age-related functional decline (421)

Excess refined carbs and added sugars, especially fructose, trigger hepatic de novo lipogenesis (DNL), increase visceral fat, worsen insulin sensitivity, and activate inflammatory and fibrogenic pathways [101,102,103,104,105,106,107,108,109,110,111,112]

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Furthermore, the administration of isoliquiritigenin reversed the downregulation of mitochondrial biogenesis-related proteins, including Nrf2, HO-1, Sirt1 and PGC1-, in human chondrocytes