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Alternatively, G-6-P may be converted into 6-phosphogluconolactone, which enters the pentose phosphate pathway, an alternative route of glucose oxidation, to also generate energy in the form of adenosine triphosphate (ATP) under the action of glucose-6-phosphate dehydrogenase (G-6-PD) (15)

This suggests that LOX-catalyzed lipid hydroperoxide production in the cell membrane promotes tumor ferroptosis (Shintoku et al., 2017)

(2015) 10:e136219

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