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However, individuals with rare genetic conditions like Lebers hereditary optic neuropathy or those with known severe hypersensitivities to cobalt should avoid these shots

A modified mutant human NNMT (mt-hNNMT) [lacking 3 amino acid residues from the C-terminus of the NNMT protein that was not observed in crystal structure] (3ROD, PDB accession code) cloned into an IPTG-inducible plasmid pJ401 expression vector was purchased from DNA 2.0 (Menlo Park, Calif.)

The secondary outcomes were the change of mean arterial blood pressure (delta MAP, %), the kinetics of arterial blood pressure, gap CO 2 , gap CO 2 /oxygen arteriovenous difference ratio, oxygen delivery (DO 2 ), oxygen consumption (VO 2 ), arterial lactate, hematocrit, sodium, and chloremia over a period of 60 min

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