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A wide variety of mutations in the Parkin gene are responsible for autosomal recessive parkinsonism in Europe

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The glutathionylated/oxidized enzymes were again purified via Ni-NTA affinitiy chromatograpghy followed by desalting on a PD-10 column as described above

While many growth factor systems have been examined as potential therapeutic targets for PD one that has been largely, and we think mistakenly, overlooked is the hepatocyte growth factor (HGF)/c-Met (its type I tyrosine kinase-receptor) system

In total, 63.2% (vs