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The peptide sequence incorporates critical modifications to native human amylin: an N-terminal lipidation with eicosanedioic acid conjugated through a gamma-glutamic acid linker, strategic proline substitutions to prevent fibril formation, and an amidated C-terminus to enhance receptor binding

Preclinical and clinical studies demonstrate that co-administration of these peptides achieves superior reductions in bodyweight, appetite, and fasting glucose than either agent aloneachieving up to a 17% reduction in bodyweight in non-diabetic individuals and a 15.6% reduction in patients with type 2 diabetes over 2032 weeks

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Cagrilintide is an amylin receptor agonist