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DAMPs can bind to and activate pattern recognition receptors on the surface of renal innate immune cells (such as macrophages and dendritic cells) and renal tubular epithelial cells, thereby activating downstream core pro-inflammatory signaling pathways such as NF-B, and inducing the massive secretion of pro-inflammatory factors including Tumor Necrosis Factor- (TNF-), Interleukin-1 (IL-1), and Interleukin-6 (IL-6) (Fu et al

special attention must be paid to factors such as size, shape, surface properties, and/or source of the materials

score 1: less than 20% higher cellularity of ribbon-oriented round nucleus cells

elegans has evolved a mechanism to learn from experience and avoid pathogens 56

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