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In a short-term study of 14 days (Jansen et al., 2018), male mice were exposed to an intraperitoneal dose of 100 and 200 mg vitamin E/kg body weight/day

In experimental contexts, dosages of 10 to 15 units per day are frequently used

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This suggests that perimenopause may represent a key window for early intervention in cognitive aging (42)

We replicated these associations in the healthy SAMS cohort, where we observed that individuals with worse memory recall had higher CognitionOrganismal and CognitionBrain age gaps (Extended Data Fig