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This intervention effectively alleviated core symptoms, including social deficits, stereotypies, and anxiety, showing a consistently strong effect across different genetic etiologies [55]

Another study reports that a significant loss of parvalbumin and somatostatin inhibitory neurons in the ventral hippocampus, which results in excitation/inhibition (E/I) imbalance, leads to anxiety-like behavior (Li et al., 2022)

It is important to consider this evolutionary component while developing new drugs because there might be variations in gene expression and cellular response in other species, including humans

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acknowledges funding from the Wellcome Trust and The Royal Society (grant nos 105942/Z/14/Z and 105942/Z/14/A), Worldwide Cancer Research (grant no