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Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Research published in Nature demonstrates that glutathione neutralizes reactive oxygen species (ROS) by donating electrons to quench free radicals, subsequently being oxidized to GSSG before regeneration by glutathione reductase

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Rats under each type of intervention were randomly divided into three sub-groups that were sampled during resting as the baseline control (CE0, VCE0, HE0), immediately post a treadmill exercise (CE1, VCE1, and HE1) and 4h post the exercise (CE4, VCE4, and HE4), with nine animals in each sub-group and a total number of 81

The Ct mean of GAPDH in the APAP group was 19.4 (SD = 1.47), while Ct mean in the APAP + PA group was 20.2 (SD = 1.14)