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They have been mostly viewed as effectors of allergy and it has only been in the last two decades that they have gained significant attention for their involvement in a range of other physiological and pathological processes

Thus, there is a growing need to implement innovative strategies for assessing drug efficacy more rapidly and with greater personalization, highlighting the urgent need for advanced in vitro models, including the immune-competent, multi-tissue RA-on-chip platforms, capable of replicating the complex interplay between immune cells and joint-resident stromal components (94, 194, 195)

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raised the p53 expression and the ratio of Bax/Bcl-2

44,45 A bevy of sedative-hypnotics have been used by clinicians to treat post-TBI insomnia