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The observations reported herein show that pro-GSH molecules represent new therapeutic agents to support immune modulation. [222] These data indicate that glutathione peroxidase-dependent control of intracellular reactive oxygen species accumulation is important not only for regulation of TH-cell proliferation, but also for modulation of differentiation into TH1, TH2 and TH17 cells.[223] See the clinical strategies described above for strategies for increasing glutathione levels