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By lowering D-2HG levels, ivosidenib helps restore normal cellular differentiation that is often disrupted in IDH1-mutant cancers, such as acute myeloid leukemia (AML) and cholangiocarcinoma

Upon activation, the MLKL complex migrates to the plasma membrane, where its accumulation forms hotspots that open ion channels, causing cell swelling, membrane rupture, and the formation of pores

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Furthermore, LRRK2 mutationsparticularly G2019Sare linked to disrupted mitochondrial dynamics, altered kinase activity, and aberrant autophagy (Franco et al., 2021

It's essential to undergo treatment under the supervision of a trained provider