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Clin Chim Acta 348 , 113120, doi: 10.1016/j.cccn.2004.05.007 (2004)

Never discontinue prescribed medications or ignore medical advice in favour of supplements

Preferably, a controlled-release pharmaceutical composition of the invention is capable of releasing a cyclobenzaprine analog into a subject at a rapid onset, so as to maintain a substantially constant or desired pharmacological activity for a given period of time, reduce or remove the effect of food on absorption, and to provide elimination of the drug and metabolites from the body with a reduced terminal elimination phase