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Description

More complexity generally means more potential degradation sites

Severe vitamin B12 deficiency can lead to memory loss, joint pain, and vision problems, among other complications

Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism