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The monochlorobimane reagent was prepared by reconstitution in DMSO per manufacturers directions

We now demonstrate that targeting CD38 with heavy-chain antibodies that selectively inhibit NAD glycohydrolase activity without inducing cell death or global CD38 blockade will boost tissue NAD + and precursor levels and sirtuin activity, reduce cellular senescence and mitigate fibrosis and inflammation in multiple organs

The Quality of Life and Symptom Control Committees of the National Cancer Institute of Canada Clinical Trials Group

doi:10.1016/j.jacc.2021.02.009 Stanescu AMA, Simionescu AA, Diaconu CC

10.1002/jnr.21950 J