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Amyloid beta-peptide (142)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression

Simard-Bisson C, Parent LA, Moulin VJ, Fruteau de Laclos B

NTA is a hexadentate ligand that coordinates Ni2+ ion and His residues in the analyte protein (natural or recombinantly synthesized with a His6 tag) bind to this coordination complex (Figure 1)

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Polyamine oxidase and diamine oxidase catalyse the production of hydrogen peroxide in a regulated way, which itself acts as a signalling molecule for the activation of defence-linked genes in plants