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The vital role of selenium metabolism in maintaining cartilage homeostasis is expected, considering its critical involvement in regulating cellular processes such as chondrogenic differentiation of progenitor cells, maintenance of redox homeostasis and DNA damage repair in chondrocytes, which are covered in the next section

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Furthermore, CSCs exhibit critical features of embryonic stem cells (ESCs) in terms of transcriptional factor expression (SOX2, OCT4, NANOG, MYC, KLF4, SALL4, and FOXM1) and signaling pathways (like Wnt/-catenin, Hedgehog, Hippo, Notch, and TGF-) [99,100,101]

To further determine whether ULK1 signaling is involved in MSM attenuation of impaired autophagy in MAFLD, the phosphorylation of ULK1 at Serine-555 (S555) was assessed