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The JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications

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In head-to-head clinical trials and real-world studies, tirzepatide consistently delivers greater weight loss (up to 22.5% vs 15%), superior A1C reduction (-2.3% vs -1.8%), and a higher proportion of patients achieving clinically meaningful weight loss thresholds

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