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[PubMed: 23334574] 5

B12 deficiency is among the most common B-vitamin deficiencies because it is not naturally found in plant foods, and several health or lifestyle factors can reduce absorption

The principal engineering upgrade of this strategy lies in its superior specificity and stoichiometric occupancy

The two-hit hypothesis in the context of aberrant neuroplasticity and environmental factors (such as trauma) is elegantly described in a review article by Rauschenberger and colleagues [ 159 ]