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Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

While evaluating the surface chemokine receptor expression on central memory Tfh cells, it was found that in pulmonary sarcoidosis peripheral blood samples contained an elevated percentage of Tfh2 (CXCR3 CCR6 CCR4+), Tfh17 (CXCR3 CCR6 + CCR4+), and dual-positive Tfh17 (CXCR3 + CCR6 + CCR4+) paralleled with significantly reduced Tfh1 (CXCR3 + CCR6 CCR4) and Tfh17.1 (CXCR3 + CCR6 + CCR4) levels [I