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Recently, its deficiency has been linked to an increased risk of thyroid autoimmunity since it impairs lymphocyte proliferation and antioxidant defenses

Sci Rep 4:17

The MET-catabolizing enzymes, Gnmt, Cbs, and Cth, are normally activated by the cycle metabolites, and liver levels increase with additional MET intake

MAPKs, including extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), and p38 MAPKs, regulate various cellular activities such as growth, differentiation, and apoptosis