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S., Mann, J

In ageing yeast, spermidine treatment triggered the deacetylation of the histone, H3, through the inhibition of histone acetyltransferases (HAT EC 2.3.1.48), suppressing oxidative stress and inducing apoptosis [115]

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The key areas and residues around the pocket in both mTYR and hTYR are noted in Fig