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For example, baicalein has been shown to attenuate multi-organ injury in inflammatory disease models by suppressing mitochondrial damage and mtROS generation, thereby preventing PANoptosome formation and inhibiting PANoptosis (Yuan T

67 The negative role of IKK in inflammasome activation appears to involve induction of autophagy, an intracellular degradation system that maintains cellular homeostasis through degradation of abnormal proteins and damaged organelles like mitochondria

Images were taken in an inverted microscope (IX83, Olympus) and an analysis for number of sprouts per spheroid was performed using NIH ImageJ software

Adv Pharm Bull 8:565

doi: 10.1189/jlb.0302105 51 RuckesTSaulDVan SnickJHermineOGrassmannR