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doi: 10.3390/fishes9120512 19 ParishCAJiangHTokiwaYBerovaNNakanishiKMcCabeDet al

Likewise abnormalities in potassium channel have been reported in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a lethal neurodegenerative disease commonly called Lou Gehrigs disease 30 , and Parkinsons disease such that potassium channel blockers are part of treatment regimen in Parkinsons disease 31

It was found that a 23-fold -synuclein overexpression in hippocampal and ventral midbrain neurons impeded synaptic vesicle release [116] while -synuclein knock-out mice displayed stronger release of DA upon stimulus [117]