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It is often linked to obesity, genetics, or a poor diet

Method Enzymology Vol

doi: 10.1186/s12951-024-02648-5 148

doi: 10.1016/j.cmet.2017.01.005 162 LeetePOramRAMcDonaldTJShieldsBMZillerCT.S

hepcidin also downregulates its synthesis through a negative feedback loop depending on circulating iron concentration to prevent iron overload in the body (Yao and Li, 2023)