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The most dramatic difference is observed when measuring protein levels between stage 1 and stage 3 konzo, where the most significant differences are observed with the lower limit of the 95% CI for unaffected siblings being 1.78 g/ml being as compared to the upper limit of 1.36 g/ml for the 95% CI for those with stage 3 (Supplementary Fig

AGXT2 knockout mice exhibit increased asymmetric dimethylarginine and reduced NO and develop hypertension 139

Experimental studies have demonstrated upregulation of KIF15 in mouse aortic VSMCs exposed to 50 nm PS-NPs

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