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It is evident that the synthesis of NMN is affected by a range of genes in microorganisms, which can substantially enhance in NMN production by the regulation of metabolism (Figure 3 and Table 6) (Camarca et al., 2021

Among them, mTORC1 plays a primary role in regulating metabolism by sensing various environmental signals, including growth factors, energy levels, oxygen, and nutrients [382]

Prebiotics and probiotics are described further below

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