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Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

Glossary cAMP cyclic adenosine monophosphate DSCs decidual stromal cells ECAR extracellular acidification rate ESCs endometrial stromal cells F6P frucotose-6-phosphate FBP fructose-1,6-bisphosphate G6P glucose-6-phosphate GLUTs glucose transporters H3K27ac histone-H3 lysine-27 acetylation hESCs human endometrial stromal cells HK Hexokinase IGFBP-1 insulin-like growth factor binding protein-1 IRS2 insulin receptor substrate 2 LDHA lactate dehydrogenase A MAPK mitogen-activated protein kinase MCT4 monocarboxylate Transporter 4 PCOS polycystic ovary syndrome PDHA1 pyruvate dehydrogenase enzyme 1 PDK4 pyruvate dehydrogenase kinase 4 PFK1 Phosphofructokinase-1 PFKFB3 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 PGR progesterone receptor PI3K/AKT phosphatidylinositol 3 kinase/protein kinase B PKs pyruvate kinases PRL prolactin SDHB succinate dehydrogenase complex iron sulfur subunit SGLT1 sodium-glucose transporter 1 TCA cycle tricarboxylic acid cycle References 1 GellersenBBrosensJJ

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10.1007/s11274-016-2124-2 56 KardaniA.SoltaniA.SewellR

doi: 10.3390/cells10102560 180 DybowskiSTorkeSWeberMS